1-hydroxypyridin-2-one (1,2 HOPO) ligands were synthesized to form bimetallic complexes containing Fe(III). 1,2 HOPO was selected due to its high affinity to Fe(III). Due to being a monoprotic acid under biological conditions our ligands form neutral tris-complexes with Fe(III) and exhibit kinetic inertness towards dissociation. Complexes can be further functionalized to contain specific targeting groups or groups to bind to proteins such as human serum albumin. These Fe(III) complexes are not anticipated to contain an inner-sphere water ligand to enhance T1 relaxivity, as do the clinically used T1 MRI contrast agents such as Gd-DOTA. Rather, the complexes contain hydrogen-bonding sites on amides to interact with second-sphere water molecules to enhance T1 relaxivity. The rigid structure of the ligands inhibits the rotation of metal centers with respect to each and contributes to increased proton relaxation of bulk water.

Designing bimetallic Fe(III) complexes as T1 MRI contrast agents

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.