Triarylmethane compounds derived from various aldehydes and indoles have been studied for their potential to treat a variety of cancers. Some of the compounds studied have exhibited selectively for cancer cells vs. normal ones. Recently, our laboratory developed a photoacid catalyzed strategy for the synthesis of triarylmethanes and 3,3’-diaryloxindoles. Through the incorporation of alkyne functional handles, we plan to synthesize a variety of triazole containing triarylmethanes and 3,3’-diaryloxindoles to evaluate their anti-cancer properties. These triazole modified compounds have the potential for divergent selectivity relative to their parent compounds, due to their unique structure. This presentation will discuss the optimization for the synthesis of alkyne containing triarylmethanes and 3,3’-diaryloxindoles, as well as the synthesis of the triazole modified structures. Preliminary biological studies will also be discussed.

Synthesis of triazole containing triarylmethanes and 3,3'-diaryloxindoles

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.