Our work has focused on the development of novel magnetic resonance imaging (MRI) contrast agents (CA) using a cluster-nanocarrier system. We have previously identified two cluster-nanocarrier systems with outstanding relaxivity: Mn8Fe4O12(O2CCH3)16(H2O)4-co-Polystyrene or Mn8Fe4-co-PS and Mn3(O2CCH3)6(C10N2H10)2-co-Polyacrylamide or Mn3Bpy-PAm synthesized via miniemulsion or inverse minemulsion conditions respectively. We have shown that incorporation of Mn3Bpy into polyacrylamide results in an 8 fold T1 relaxivity enhancement compared to the cluster alone and 10 fold higher than that of clinically used gadolinium chelates. We are investigating the relaxivity mechanisms behind this enhancement (water exchange, magnetic coupling, and rotational motion). We are also investigating new nanocarriers to attain greater blood half-lives via modification of nanocarrier composition as well as modifying surface coverage to achieve long term multi-modal MRI contrast agents.

Mechanism of high relaxivity in iron/manganese-based cluster nanocarrier systems for use as MRI contrast agents

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.