Synthesized hexanethiolate monolayer protected Au25 nanoclusters (MPCs) are used as biochemical markers with enhanced fluorescence. They are contained in optoelectronic devices, and act as drug delivery vehicles of reduced toxicity within the human body. These Au25 nanoclusters exhibit optimal optical absorption in the near-infrared region of the spectrum and thus are minimally invasive to the human body. Furthermore, Au25 nanoclusters are magic numbered clusters, and have increased stability due to their closed energy shell energy configuration of 8 valence electrons. They are superatom clusters, allowing the transfer of electrons between the central gold core and the ligand attached and owing to their ultrasmall dimensions, their surface area-to-volume ratio increases exponentially allowing them to be administered in low concentrations with increased payload per kilogram. Due to the great versatility of applications of these unique Au25 clusters, the study of Au25 nanoclusters is of great urgency so that we can better understand how to tailor such clusters for optimal use. Tagging Au25 clusters with fluorescent dye allows for increased fluorescence based biological imaging. In addition, once antibodies are attached to these nanoclusters, they can potentially be used as drug delivery vehicles within the human body. One way of tailoring these clusters for the previously listed uses is through a ligand exchange reaction. During this challenging and precise reaction, the protective core-stabilizing hexanethiolate ligand of the unexchanged core clusters becomes exchanged with a new ligand of choice that is introduced to the reaction. The added ligand will either replace the existing orthogonal semi-ring shell of the unexchanged cluster or add to it, giving it a new set of unique optical and electrochemical properties. The objective of this project is to synthesize ligand exchanged thiol-protected icosahedral and bi-icosahedral nanostructures with chromophores to produce desired optical and electrochemical properties. Fluorescent ligands such as anthracene thiol and coumarin thiol are used and the results will be presented.

Chromophore ligand exchanged Au25 nanoclusters: Optical and electrochemical properties

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.