Catheter-associated urinary tract infections (CAUTIs), caused by the biofilm formation on the indwelling catheters, worsen the problem with the resistance development, being the most common infections in the patients in health care facilities. Bacterial biofilms account for 60 % of CAUTIs and are global treat to the human health due to their resistance to antibiotics, leading to increased time of hospitalization, significant medical costs and poor treatment outcomes. The need to control and prevent CAUTIs calls for development of novel antibiofilm strategies with low probability for selection of new resistant strain. In this work, urinary catheters were simultaneously coated with adhesives-degrading antibiofilm enzyme amylase and antibacterial zinc oxide (ZnO) nanoparticles (NPs) in a one-step ultrasound assisted process. The coating of these two compounds on the same surfaces resulted in a strong synergism and significantly reduced the biofilm formation of Escherichia coli and Staphylococcus aureus by 54 % and 80 %, respectively. Moreover, these nanocoatings demonstrated stability and impeded the bacterial attachment and biofilm formation on the catheters under dynamic conditions. The developed coated catheters did not induced toxicity towards human fibroblast cells line BJ-5ta, HaCaT keratinocytes, and demonstrated 100 % biocompatibility over 7 days incubation. Taken together, such catheter with co-therapeutic compounds of amylase and ZnO NPs could be promising strategy for prevention and control the CAUTIs.

Simultaneous sonochemical functionalization of urinary catheters with biofilm matrix degrading amylase and antibacterial zinc oxide nanoparticles for prevention of bacterial infections

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.