Dendrimers are multi-functional, monodisperse, globular macromolecules with high structure fidelity. They are made up of a series of branched polymeric arms that emanate from a central core leading to many end groups at its periphery. These peripheral end groups form what is referred to as the “outer shell”. This outer shell represents the primary interface between the dendrimer and solvent, therefore, changes in surface functionalization can have a significant impact on the solvent compatibility of these polymers. Though the impact of solvent quality on the solution size of various polymers has been explored in detail, solvent effects on dendritic molecules has not been explored to the same extent. Due to their “spherical” nature, it is assumed that the relative size of a dendrimer does not change greatly between solvents. This may be due to the inability of the branched arms to significantly expand or collapse relative to the core (comparative to analogous linear polymers) owing to steric barriers, especially at higher generations. It is expected that a linear polymer of an equivalent molecular weight would have a greater degree of size change relative to the quality of the solvent due to its innate flexibility and access to a wider range of conformations.

Exploring solution size variation of linear and dendritic bis-MPA analogues in a range of solvents

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.