Phantoms are used as tissue-mimicking materials in the field of radiotherapy. We employed nanocellulose and its derivatives: cellulose nanofibrils, and several grades of cellulose nanocrystals, including sulfated, desulfated, and their oxidized derivates, to transform gelatin phantoms suitable for hyperthermia fat phantoms. Nanocellulose forms entangled fiber networks with water holding capacity, which works as reinforcement in the preparation of hydrated oil- gelatin composites. The mentioned phantoms require a thermal and dielectric equivalence of the mimicked tissue. A successful fat phantom has low permittivity (ε=11) and low conductivity (0.08 S/m, within the frequency band of 100MHz and 2GHz) coupled with mechanical strength enabling a self-standing and cuttable phantom body.<br/>Determination of storage and loss moduli as a function of temperature in small deformation, rheometry, and large deformation, Young modulus, proved physical and chemical crosslinking of nanocellulose and its derivatives in the gelatin matrix to be vital to facilitate the thermal stability and adequate resistance to deformation. Without the oxidative modification, the gel interactions were non-covalent. The tuning of the crosslinking type and rate is an additional controllable for stabilizing the system. Oil/water composition is used to adjust the permittivity and conductivity to the target level.<br/>We will discuss the approaches for achieving successful phantom as well as the role of the morphology of the oil droplets in the dielectric properties of the phantom.<br/>

Nanocellulose reinforcement for hyperthermia phantoms

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.