Zebrafish (<i>Danio rerio</i>) has become an effective model organism for the study of developing biology and complex brain disorders. Genetic screens of zebrafish phenotypes indicate similarities to human diseases, and protein sequences of drug-binding sites in zebrafish and human show a high degree of conservation.  We have designed, synthesized, and characterized photostable single-nanoparticle plasmonic optical probes and single nanoparticle plasmonic spectroscopy and imaging tools for mapping the nanoenvironments of developing zebrafish embryos.  We have also studied transport, biocompatibility, and toxicity of nanoparticles in early development of zebrafish embryos in real time. We have shown that single Ag and Au nanoparticles resist photodecomposition and blinking and can be directly monitored in embryos for an extended period of time. Furthermore, individual Ag nanoparticles exhibit size-dependent LSPR spectrum (color), which permits us to probe their diffusion, transport mechanism, and biocompatibility in living embryos in real time, and to probe investigate the embryonic fluids (e.g., viscosity) at nanometer spatial resolution in real time.  The work was supported by NSF and NIH.<br/>

Spectroscopic tracking of single plasmonic nanoparticles for probing nano-environments of developing embryos

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.