The utility of a Lewis acid is dependent on its effective strength in solution. The simple definition of Lewis acidity affords a vast array of Lewis acids which complicates universal measurement. While both experimental and theoretical methodologies exist, they often lack consistency and universality. In an attempt to address this, our team has developed a fluorescence based method to measure Lewis acidity, with which a wide variety of Lewis acids have been analyzed. By utilizing multiple probes and chromaticity based analysis, the FLA method provides a direct solution-state measurement of the Lewis acid without dependence on a specific Lewis base, and has shown to be robust against a wide variety of reactive species. From boranes and heavier group 13 acids to cationic species of boron, silicon, and phosphorus, even transition metal species, our method provides a single scale by which to compare a wide scope of Lewis acids. The FLA method will be presented along with a summary of Lewis acid measurements and trends, including several acids not previously measured by other means.

Fluorescent Lewis acid/base adducts (FLA): Simple method for determining Lewis acid strength

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.