Studies of reactions within yocto-liter reaction flasks are an important part of the drive towards more efficient and/or unique chemical conversions. In our ongoing studies with water-soluble, dimeric capsules formed from Positand 1 (P1), we have been examining the effects of dissolved anions on cyclization reactions. In this presentation we will reveal how dissolved salts outside the host affect the cyclization of 12-bromodecane-1-thiol inside the capsule. Our studies utilizing <sup>1</sup>H NMR spectroscopy reveal that relatively charge-diffuse anions can bind to the outside of the capsule, attenuate the electrostatic field generated by the cationic water-solubilizing groups, and hence affect rates of cyclization. Thus, our results show that extrinsic species dissolved in the aqueous solution are capable of tuning reaction rates of processes within these yocto-liter flasks.

Anion effects on reaction within hydrophobic yoctoliter spaces

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.