Glutamic acid decarboxylase (GAD) 65 and 67 catalyzes the decarboxylation of glutamate to GABA, a potent neurotransmitter. GABA regulates cognition, behavior and physiological responses to stress. Behavioral models are routinely used to detect and measure anxiety. However, work remains to connect behavioral models of anxiety with specific biomarkers for the condition in the brain. A Long-Evans rat model of anxiety was used, raising the animals in group-housed conditions or in social isolation from weaning to adulthood. Behavioral tests including an elevated plus maze and open field to assess anxiety in both groups. The level of GAD in the prefrontal cortex of each rat population was determined by western blotting and will be presented.

Measuring glutamic acid decarboxylase (GAD) isoforms as biomarkers of anxiety

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.