Recently, we have developed and synthesized a series of tridentate pincer ligands, each possessing two sulfur- and one nitrogen-donor functionalities (SNS), based on bis-imidazole or bis-triazole precursors. The tridentate SNS ligands incorporate thione-substituted imidazole or triazole functionalities. We have prepared somewhat rigid ligand systems (<b>1a-c</b>) through the use of 2,6-dibromopyridine as a ligand precursor. In addition, we have prepared more flexible ligand systems by employing the starting material 2,6-(dibromomethyl)pyridine to introduce a methylene linker into the pincer ligand (<b>2a-c, 3a-c</b>). We have metallated these ligand precursors to form zinc(II) complexes containing these tridentate ligands. We are now preparing cobalt(II) complexes that contain these ligand precursors. The cobalt(II) complexes are cobalt model complexes for liver alcohol dehydrogenase. The complexes have been thoroughly characterized using the following techniques: NMR Spectroscopy, ESI-Mass Spectrometry, electrochemistry, UV-Visible, EPR spectroscopy, and single crystal X-ray diffraction. We are screening the complexes for the stoichiometric reduction of aldehydes and ketones using a hydrogen donor. The reactivity studies will be presented in this poster.

Reactivity studies of cobalt(II) SNS pincer model complexes for liver alcohol dehydrogenase

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.