Infectious diseases caused by bacteria are responsible for millions of new infections and deaths per year. The continued spread of drug resistance, both in terms of geography and extent of resistance to approved therapies, represents a global health pandemic. To address this issue, we have focused on novel approaches to discover antibacterial small molecules and probe their mechanism of action. We have developed a platform for elucidating intrabacterial drug metabolism (IBDM). In this talk, we will discuss the fundamental basis of the approach and its application to understand the mechanism of action of select antibacterial agents with a specific focus on antitubercular small molecules. The result has been increased understanding as to 1) how bacteria respond to xenobiotics and 2) how to design better therapeutic agents.

Probing intrabacterial drug metabolism

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.