Amphiphilic block copolymers such as PEGPLA and PEGPCL can self-assemble in aqueous solutions generating polymeric micelles useful as drug delivery systems. In this study we will present the self-assembling properties, micelle stability, cargo protection, docetaxel loading and release profile of polymeric micelles generated from interfacially-engineered triblock copolymers PEGPBOPCL [1]. We will reveal how the engineered interfaces in these block copolymers selectively stabilize the polymeric micelles in blood vs at tumor site [2,3] and how the same interfaces affect the drug loading and release profile, in vitro, as well as in vivo, in an orthotopic model of triple negative breast cancer in female SCID mice. <br/><br/>

Self-assembled polymeric micelles with tuned interfaces for docetaxel delivery to triple negative breast cancer

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.