Multivalency plays a major role in most biological molecular recognition processes. For instance, multivalent interactions are the driving force in virus attachment to the cell surface at the early stage of infection process. The development of new drugs with multivalent ligand representation that will inhibit the virus-cell association is considered as an advantageous alternative for the treatment of severe viral infections such as Influenza. The design of such drugs includes the synthesis of complex compounds as dendrimers, fullerens, polymers etc. and requires time-consuming multistep organic synthesis. Here we present a new concept for multivalent ligand representation, reversible self-assembled monolayers. These layers are pH-swithchable version of self-assembles monolayes. Unlike SAMs, the rSAMs demonstrate lateral mobility and enhanced affinity towards hemagglutinin. These layers mimic the complex multivalent carbohydrate arrays present on the cellular surfaces thus represent an ideal platform for virus detection and for engineering of multivalent virus inhibitors.

Reversible self-assembled monolayers as a multivalent platform for virus detection and inhibition

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.