Intercalation is a process by which planar, mostly aromatic compounds can insert themselves between the nucleic acid base pairs of DNA. DNA intercalation can result in inhibition of DNA replication and reduction of the growth of cancer cells. Acridines are one major class of known DNA intercalators. This research project focuses on the formation, preparation and testing of acridine analogues. The information gained from testing these compounds can be used to better understand DNA intercalation. Analysis of compounds will be done using <sup>13</sup>C NMR, <sup>1</sup>H NMR, IR, and GC/MS. Further study will include functionalization and synthesis of more complex acridine analogues.

Derivatives of acridine used for DNA intercalation

Macromolecular Chemistry: The Second Century

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