The goal of the crystal engineer to design solids with predictable properties is generally predicated on the idea that molecular components that form an organic solid (i.e. single-component, cocrystals) will assemble via supramolecular synthons.  While supramolecular synthons will typically form with success vis-a-vis organic solution-phase chemistry, a last 'stance' in crafting the structure of an organic solid may likely depend on influences of polymorphism and related pseudopolymorphism. The ability of components that make up a crystal lattice to form different crystal structures - exhibit polymorphism - can affect properties such as solubility, gas uptake, and reactivity, and have ramifications, for example, to legal issues surrounding pharmaceutics.  The common practice of chemists to form crystals from solution means that it is important to consider the crystal landscape to involve incorporation(s) of solvent - also termed pseudopolymorphism.  In this presentation, we will present examples of organic crystals that exhibit polymorphism. Examples from our laboratory of polymorphic binary cocrystals will be discussed, with a focus on impacts of solid-state reactivity (e.g. [2+2] photodimerization) and relation to pharmaceutics.

Polymorphism: Cocrystals and solid-state reactivity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.