Liver X receptor (LXR) is a ligand activated nuclear receptor that plays a key role in many cellular pathways in the body such as regulating cholesterol, bile acid levels, regulation of glucose, skin development, and homeostasis. Being able to control the LXR enzyme could mean new medicinal ways of treating certain diseases. When LXR is activated, it lowers cholesterol levels which could treat diabetes and block the growth of cancer cells. Computational studies have shown that the molecule containing an imidazole core would interact best with LXR. In our group, we synthesized imidazole derivatives. The reaction used to synthesize the imidazoles is a two step reaction. For the first reaction, substituted benzylamine and substituted acteophenone are reacted together to create the intermediate, substituted N-Benzyl-1-phenylethanimine. For the second reaction, the  intermediate is reacted with more substituted acteophenone to create the desired imidazole. As the reaction is perfected different substituents actephone and benzylamine will be used to synthesize different substituent imidazoles.

Synthesis of 1,2,4-trisubstituted-1H-imidazoles as LXR modulators

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.