Photodynamic therapy (PDT) has potential use in the treatment of cancer and other health disorders. PDT utilizes light and a photosensitive agent that once activated by light generates singlet oxygen that affects surrounding cells. Metalloporphyrins have been shown to accumulate in tumors as the result of preferential binding to low-density lipoproteins. Additionally, gallium(III) porphyrins have been shown to be effective potential photosensitizers for PDT. The goal of this research was to synthesize and characterize the novel photosensitive agent, GaTPP-DIPA, as a PDT agent. The GaTPP-DIPA was purified using column chromatography and characterized using IR, UV-Vis, and NMR spectroscopies, purity was determined using HPLC. Cytotoxicity testing of the GaTPP-DIPA using U87 glioblastoma cells in both light and dark conditions determined that novel material has potential as a next generation PDT agent.

Photodynamic therapy potential of a novel water-soluble gallium porphyrin

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.