As the complex biology being interdicted by today’s drug discovery groups increases, so too does the rise in overall synthetic complexity of the molecules themselves required to achieve selective therapies.  At Amgen, the molecular of our small molecules entering development over time has increased requiring new and innovating methods to access these new molecular entities in efficient fashions.  Often, these methods can lead to new molecular architecture previously difficult to come by even at discovery scale.  This talk will take a historical perspective over Amgen’s past 15 years of small molecule process development and build-up of novel innovative catalytic methodologies to assemble the drug targets.  The topics will range from new catalysts for cross-coupling reactions to new stereoselective transformations executed on multikilogram scale.   <br/>

Molecular complexity the driving force for chemical process innovation at Amgen

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.