Despite all advances that were made in recent years in the field of synthetic polymer chemistry, still a significant gap between artificial macromolecules and biopolymers exist, namely the ability to control the specific sequence within a polymer chain and the ability to create monodispüerse polymers. While some synthetic techniques have emerged to bridge this gap, only few examples have been put in practice. Iterative step growth and click chemistry are typically employed. Yet, radical addition reactions are of high interest in this respect, as they can create materials that are analoguous to classical polymers.<br/> <br/>Various approaches based on controlled radical polymerization techniques towards both sequence defionitiona nd monodispersity are discussed and challenges and intrinsic limitations put in perspective. Any radical addition technqiue will require sophisticated purification steps in order to make materials monodisperse, or at least bring them close to monodispersity. As method of choice, flash chromatography is an interesting tool. In this contribution specific focus is thus put on the synthetic scope of RDRP methods for the buiild-up of sequence-defined materials. Next to the creating of sequences, and theiir correlation to oligomer properties, also the effect of discrete molar masses on physical properties such as the glass transition temperature and diffusiovity of species will be outlined.<br/>

Monodisperse acrylate and acrylamide oligomers: From synthesis to function

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.