Antioxidants prevent the development of cardiovascular disease, the leading cause of morbidity and mortality in the world. In this study, we examine the association between antioxidant activity of two common dietary antioxidants and the biological environment of serum and hypertriglyceridemic serum. Antioxidant activity is measured via a method commonly known as FRAP, or the ferric reducing activity of plasma. Catechin exhibits greater antioxidant activity than ascorbic acid. Both antioxidants exhibit similar activities in serum with normal triglycerides. Catechin shows a pronounced enhancement in hypertriglyceridemic serum. Antioxidant activity is also measured by another method known as DPPH, or 2, 2-Diphenyl-l-picrylhydrazyl. However, the protocol produced inconsistent data so we are currently developing a more robust method. We compare these experimental findings to computational models that examine the stability of the antioxidants using free energy and bond dissociation energy values following a hydrogen atom transfer (HAT) mechanism. The computational results corroborate the experimental findings and demonstrate the superior antioxidant power of Catechin.

Enhanced antioxidant activity of catechin in hypertriglyceridemic serum: Experimental and computational analyses

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.