The current development of chemical or biochemical sensors is still mainly based on the specific molecular recognition, especially “lock and key” principle (Figure 1), in which a target-specific recognition unit and a signal transduction component are always needed. Such ideal approaches include aptamers, antibodies, enzymes, other various bioconjugation interactions or even some non-specific conjugates. In general, many physiological processes or metabolism are linked with multiple chemical species and only a single sensor could not always achieve. So precise determination of biological or chemical compositions is vital to disease theragnostic with complicated pathogenesis. However, it seems to need more massive and tedious work to access target-specific sensors by trial and error, because the design of sensory method is not always valid in some situations. Diminishing and overcoming the effects from interferences are the chief problems of analytical chemistry. When a sensor meets a group of analytes with similar structures or physical and chemical properties, the reliability of this strategy is often doubtful. The novel and smart chemical“nose-tongue”mimic sensor array is promoted toward this key point. In this issue, several sensors are combined in an array format, which is very similar to human-being sensory cells that the nose or tongue can accept external stimuli from environment. Then such responses of each cell are collected and transferred in chemical or electrical signals to cerebral cortex, where it will tell body what it smells or tastes (Figure 1). The same principle as chemical “nose-tongue” mimic sensor array, signals from different recognition components come together and are handled by data mining process (e.g. principal component analysis), and then it will give the results of what it senses or what it contains. Therefore, based on the abundant database and protocol programming, the different species can be directly exhibited in 2D or 3D graphs, which reflect their different level of separation.

Design of smart chemical 'nose/tongue' sensors for pattern-recognition-based biochemical sensing applications

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.