Polymer based, nanosized particles (such as dendrimers and polymers micelles) can be successfully used for the solubilisation of various poorly soluble therapeutic drugs, and demonstrate a variety of attractive properties in drug delivery and nanomedicine applications. Dendrimers are a class of multi-functional polymers consisting of highly ramified (dendritic) macromolecules, that provide a source of surface functionality and interior void space. Their multivalent surface functionalities, that can be linked to drug molecules or ligands, makes them well-suited for use as carrier of therapeutic molecules in drug delivery applications. Polymeric micelles formed by amphiphilic block copolymers, are of a special interest as they possess high stability (both in vitro and in vivo), and good biocompatibility. These systems combine an enhanced colloidal stability together with the inclusion and transport properties of host-guest (drug carrier) systems, and represent promising classes of nanomaterials suitable for advanced applications in the field of biotechnology and nanomedicine. Understanding the fundamental physico-chemical properties of those polymer-based systems, in terms of interaction strength, colloidal stability, nanocarriers size and morphology, stimulates the development of formulation polymeric nanocarriers with enhanced properties, such as the drug encapsulating capacity, prolonged circulation time, and colloidal stability in the human body environments. We present some recent results which show how the effective intra- and inter-particles interactions, as well as the solution environment conditions, are crucial parameters for the modulation of the degree of structural organization in solution, suitable for a number of potential applications in the field of biotechnology and nonomedicine.

Self-assembly and interaction in polymer nanocarriers for drug delivery applications

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.