Sulfur (VI) fluoride exchange (SuFEx) is a new click reaction, which creates stable structures via sulfate or sulfonate linkages. SuFEx has already found many applications, from synthesis of macromolecules, surface chemistry, medicinal chemistry, and biological probes. However, very limited availability of SO2F2for lab purposes has limited wider use of this chemistry. We have developed an ex-situ, on water, safe and inexpensive route for SO2F2synthesis and applied in the synthesis of high molecular weight polysulfates from parent phenols. The reaction developed here is atom economical and results in complete cycle where byproduct generated can be reused in the same reaction cycle, virtually eliminating the chemical waste. The SO2F2was also found to be a stable electrophilic dehydrating reagent in various organic transformation for synthesis of nitriles and amides.

Sulfuryl fluoride: Lab scale synthesis and applications in SuFEx chemistry

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.