Bridged aza-polycyclic ring systems containing seven membered rings are found in a number of biologically active molecules. This work explores the creation of diverse aza-polycyclic skeletons via a variety of reactions performed on a common aza-Michael adduct of tricarbonyl(tropone)iron(0). Specifically, solvent-free Michael addition of 2-bromo-2-propen-1-amine to the aforementioned iron complex proceeds in good yield. Following protection of the amine, the resulting vinyl bromide is poised to participate in several different potential cyclization events.

Accessing diverse bridged azapolycycles from tricarbonyl(tropone)iron

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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