Alkenes are one of the most ubiquitous functional handles in organic chemistry.  In this study, a strategy to introduce alkenes through the remote desaturation of aliphatic C-H bonds was investigated.  Utilizing Copper and Iridium catalysts, a series of distal desaturated amines were synthesized.  The versatility of this privileged scaffold is showcased by the streamlined synthesis of pharmaceutically relevant piperidines and pyrrolidines.<br/>

Vicinal C-H functionalization of amines enabled by an interrupted Hoffman-Loffler-Freytag mechanism

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.