Methanogenesis is the biological production of methane and is utilized by methanogenic archaea as a form of anaerobic respiration to generate energy. Methane is both a potent greenhouse gas and a valuable energy source; therefore, understanding the chemistry of biological methane production could lead to greenhouse gas mitigation strategies and inform bioenergy technologies. The methane forming step of methanogenesis is catalyzed by methyl-coenzyme M reductase (MCR) and its prosthetic group, coenzyme F430, a unique nickel-containing tetrapyrrole. Recently, multiple F430 variants have been discovered in several methanogenic species, including the two model methanogens, Methanococcus maripaludis and Methanosarcina acetivorans. Our recent research indicates that at least two of these variants, mercaptopropionate-F430 and vinyl-F430, are produced primarily in late-stage growth, possibly in response to nutrient depletion, as opposed to early-stage growth where nutrients are plentiful. Future research will further elucidate the influence of these F430 variants on MCR catalysis.

Investigating the production of coenzyme F430 variants in methanogenic archaea

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.