Amaryllidaceae isoquinoline alkaloids, as well as their analogs, have long been of interest in research for drug discovery due to their biologically active nature. Many of these compounds have been found to be anti-tumor agents. Moreover, there have also been studies that show the effectiveness of these molecules against diseases such as Yellow Fever and other RNA-containing flaviviruses. Though these compounds are pharmaceutical prospects, their low natural abundance lowers their potential to become useful drugs. For this reason, many synthetic chemists have pursued novel routes to synthesize a wide variety of these compounds.<br/>Techniques toward the synthesis of Amaryllidaceae natural products are presented herein. Manipulations were tested and optimized on a model system to save both time and funds while developing a synthetic pathway to be utilized in the formation of more complex compounds. Setbacks such as introducing additional hydroxyl groups have been encountered. However, adjustments are being made to alleviate such difficulties. Ultimately, the proposed scheme will allow for the synthesis of multiple biologically active alkaloids.

Steps towards the total synthesis of Amaryllidaceae alkaloids

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.