In this talk I will describe recent results from my laboratory related to two projects.  First, we have examined the pathogenic form of alpha-synuclein fibrils including samples derived from post-mortem human brain tissue.  I will describe the methods developed in order to determine high-resolution structures of these fibrils.  Second, I will describe our efforts to determine the structure of amphotericin B (AmB), an antifungal drug that acts in killing fungal cell by extracting ergosterol from the fungal membranes.  We have applied a range of multidimensional solid-state NMR studies to determine the structure of AmB as well as it complex with ergosterol.

Solid-state NMR spectroscopy of fibrils and drug interactions

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.