A key challenge for self-assembly is to reproduce Natures' ability to assemble multiple functional entities in defined locations and at specific times. Such assemblies modulate complex adaptive networks that control biological processes (e.g. intracellular signalling cascades); multiple molecular recognition events happen simultaneously AND sequentially, requiring individual components to interact selectively with one partner at one point and then with another partner at a different point in a given process. This presentation will describe a series of new building-blocks capable of well-defined hydrogen-bonding interactions made in one or two steps.1-2 These motifs form heterodimers with tunable associations constants (102&gt;104 M-1). The presentation will then describe how these hydrogen-bonding motifs together with others taken from the literature can be used to carry out sequential self-sorting and to develop self-sorting networks.3-4

Self-sorting networks using hydrogen-bonding building blocks

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.