New methodologies for the preparation of the isoxazoline ring system are useful in drug design. One such methodology involves the ring closure of an α,β-unsaturated oxime. This method was explored using chalcones, which are readily available through the aldol condensation of a benzaldehyde and an acetophenone derivative. The oxime is formed by reaction of the chalcone with hydroxylamine hydrochloride and sodium acetate. The ring closure of the oxime was studied, and details of the synthesis and spectroscopic data will be discussed, including the effects of electron donating and electron withdrawing substituents. <br/>

Preparation of isoxazolines via ring closure of oximes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.