Oxazoles, five-membered aromatic heterocycles containing both nitrogen and oxygen atoms, have unique structural and physical properties that are desirable in both medicinal and materials chemistry. Generally, oxazole synthesis involves intra- or inter-molecular carbonyl condensation chemistry in the presence of strong acid or harsh dehydrating agents. Through this study, a mild, radical-based strategy has been developed, which converts simple alcohols and nitriles to oxazoles via successive C-H functionalization of imidate intermediates. This modular approach allows for rapid synthesis of a library of oxazoles bearing diverse substitution patterns in high yields.<br/>

Oxazoles from alcohols and nitriles via tandem hydrogen atom transfer

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.