Multicomponent coupling reactions (MCRs), such as the Ugi-Smiles reaction, can provide direct access to diverse scaffolds from simple starting materials. In the presence of methanol and a conjugated aldehyde, a novel five-component oxy-Michael Ugi-Smiles reaction was observed. This process tolerates a range of substituted alcohols and isocyanides, with moderate, but promising, yields (45-65%). Current efforts are focused on variation of the amine and aldehyde components, as well as minimization of a competitive Ugi-Smiles product.

Amine variation in oxy-Michael Ugi-Smiles processes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.