Amination of sp3 C-H bonds is of great pharmaceutical and synthetic importance. There has been extensive work in the past few decades on the use of common earth metal catalysts, such as copper, for amination reactions. This potentially alleviates the reliance on more commonly used catalysts (Pd, Rh, Rd, etc.) which are generally more expensive and harder to obtain. There is evidence to suggest that the addition of peroxides in base metal-catalyzed amination reactions can lead to increased yields via a theoretical Cu-OH intermediate. To investigate the effects of peroxides on copper-catalyzed amination, toluene was aminated using PhI=NTs with catalytic amounts of Cu(OAc)<sub>2</sub> in the presence of benzoyl peroxide.

Effects of peroxides on copper-catalyzed alkane amination

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.