Hepatocellular Carcinoma (HCC), a major type of primary liver cancer, is the third leading cause of cancer-related mortality globally. The main causes of HCC are Hepatitis C and B viral infections, followed by excessive alcohol consumption, but the fastest increasing cause of this cancer is due to metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). Metabolic disease-associated HCC has been linked to biological processes such as chronic inflammation due to pro-inflammatory cytokine secretion and lipotoxicity. A betting understanding of the progression of HCC is important to improve treatment options as well as metastatic prevention. Our project investigates the cytokines secreted by the liver in response to excess saturated fatty acid palmitate. An antibody array indicated that the cytokines CINC-1 and VEGF are secreted in response to this fatty acid treatment. In our experiments, we have observed a 3-fold increase in the secretion of CINC-1 in hepatoma cells treated with palmitate compared to a vehicle control. This increase was not observed in AML-12 hepatocytes suggesting that it is specific to HCC. Elevated CINC-1 levels began within two hours of palmitate treatment and were also dose-dependent. When co-treated with an unsaturated fatty acid oleate or in the absence of glucose, CINC-1 secretion was reduced. We are currently investigating the mechanisms involved in the production of CINC-1 in response to palmitate treatment.<br/>

Hepatoma cell response to saturated fatty acids

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.