Self-assembled nanoparticles including micelles and liposomes have been studied as drug carriers and practically applied in clinics. However, their drug efficacy is not very high in vivo. This is due to the unstable nature caused by the dynamic self-assembly system. Those particles would easily be decomposed after administrating into blood stream by dilution effects, interacting with plasma proteins, and the high shear stress in blood vessels.<br/>In this study, we have prepared an amphiphilic compound bearing poly(ethylene oxide) (PEO) as a hydrophilic part and methacryloyl group at the end of alkyl chain. Radical polymerization was conducted for the nanoemulsion composed of the amphiphile and divinyl benzene (DVB), producing cross-linked nanoparticles bearing PEO chains. We named the particles furry nanoparticles (f-NPs) and characterized their structures using small angle scattering measurements. The particle stability was improved compared to that of the micelle composed of the amphiphile while the structure remained in core-shell structures just like that of the micelle. Further, the size of f-NPs and their drug loading ratio can be easily controlled by changing the molar ratio of the amphiphile to DVB. The particle stability in vivo was also compared to that of the micelle.

Furry nanoparticles: Cross-linked nanoparticles prepared via nanoemulsions and their robust stability <i>in vivo</i>

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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Furry nanoparticles: Cross-linked nanoparticles prepared via nanoemulsions and their robust stability in vivo