Mechanochemistry promises to achieve more environmentally friendly syntheses by reducing solvent use and removing most liquid waste. In this lab, aldehydes and ketones were transformed into oximes using mechanochemistry. Thus, a mixture of 9-fluorenone, hydroxylamine hydrochloride, and sodium acetate trihydrate were mechanically crushed with a stir rod in a test tube at 80°C producing fluorenone oxime in 75% yield. NMR and IR spectroscopy and melting point confirmed formation of the oxime. Other ketones and aldehydes such as camphor and vanillin were also converted to oximes <i>via </i>mechanochemistry.

Aldehyde and ketone to oxime transformation via mechanochemistry

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.