Nitrite and N2O are the only two known reported products of the spontaneous self-decomposition of trioxodinitrate(II) anion, Angeli’s salt, in aqueous medium in the pH range 4-10. Since 1905, the self decomposition of Angeli’s salt has been consistently interpreted by a mechanism involving a reactive intermediate, nitroxyl (HNO). We report that at higher initial concentrations of Na2N2O3 (HN2O3– ≥ 1 mM) in aqueous phosphate buffer (pH 7), hydroxylamine is formed with small but significant yields; hydroxylamine was determined by the highly specific green indoxine derivative (after reaction with 8-hydroxyquinoline) at 710 nm. As HNO is isoelectronic with formaldehyde (CH2O), as it appears, HNO undergoes self-oxidation/reduction, which is similar to the Cannizzaro reaction of formaldehyde. Our finding of hydroxylamine as an additional product in the self-decomposition of Angeli’s salt is significant in the context of current resurgence of HNO chemistry and biochemistry, including nitroxyl-based therapeutic for cardiac relaxation. Hydroxylamine is a known inhibitor of mitochondrial respiration, HNO capture and reduction at the oxygen binding site of cytochrome c oxidase could be significant. We will present preliminary results on the reaction of HNO at the oxygen binding site of cytochrome c oxidase.

Revisiting the decomposition of trioxodinitrate(II): Novel duality in nitroxyl (HNO) redox chemistry

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.