The purpose of this work was to fabricate the gelatin-based nanofibers with core-shell structure by electrospinning of corn oil-in-water emulsions. The presence of the core-shell fiber matrix allowed the incorporation of hydrophobic compounds in the core section, which can effectively avoid the burst release of the encapsulated bioactive compounds without compromising their bioactivity. In scanning electron microscopy images, the beads-in-string fiber morphology by electrospinning of gelatin-stabilized emulsion was observed. The confocal laser scanning microscopy and scanning electron microscopy observations confirmed that the encapsulated oil was randomly distributed as the core, especially inside the beads. The electrospun fibers showed good storage stability and thermal decomposition stability. Furthermore, an oppositely charged polysaccharide gum arabic was added to the primary gelatin-stabilized emulsions to develop the bilayer emulsions, and the surface coating resulted in the enhanced stability of emulsions, leading to the production of smooth and bead-free nanofibers. Then genipin was used as a safe cross-linking agent for gelatin-based electrospun fibers, in order to improve the mechanical properties of the electrospun nanofibers and to preserve the fiber morphology when exposed to water. These results contributed to a good understanding on the emulsion electrospinning of food materials and provided a novel nanoencapsulation strategy, which was expected to enhance the encapsulation efficiency, stability, and bioavailability of hydrophobic compounds, as well as to achieve targeted delivery and controlled release.

Gelatin-based nanofibers by emulsion electrospinning: Novel nanoencapsulation approach for bioactive compounds

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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