Heightened cost pressures are challenging biopharmaceutical facilities to operate with increased speed and flexibility. Process intensification has become a strategic focus aimed at efficiently utilizing existing facility assets to deliver increased productivity. A key example of this is utilizing perfusion in place of traditional batch or fed-batch processes in upstream. Adoption of perfusion in N-1 bioreactors yields a reduction in process time and/or increase in manufacturing capacity without increasing volume capacity. A key technology within the perfusion application is the mechanism for removing fluid from the bioreactor while maintaining the cells in the system. Historically, the technologies available for retaining cells in the bioreactor have had limitations either mechanically, or with separation performance aspects such as throughput, efficiency, product retention, or process scalability. Due to recent advances in the cell retention technologies, in parallel to advancements in cell line and media development, perfusion processes are becoming a more viable alternative to expand performance beyond what traditional batch/fed-batch platforms can attain. To address this market need, MilliporeSigma is developing a family of pre-sterilized, high-throughput perfusion filtration solutions/systems with ease-of-use in mind and scalable from bench to production. 

Cellicon<sup>TM</sup> perfusion solution

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

CelliconTM perfusion solution

Cellicon^TM perfusion solution