The enantioselectivity of ATH using arene/Ru/TsDPEN catalysts, including tethered versions, in reductions of ketones is known to be predominantly influenced by a favorable “edge-face” electronic interaction between electronic-rich groups in the substrate and H atoms on the electron-deficient η<sup>6</sup>-arene ring of the catalyst.Typical substrates such as diaryketones and aryl/alkynyl ketones having potential π-system in the both sides of carbonyl can compete for “edge-face” interaction with catalyst resulting in lower product enantiomeric excess (ee). However, ATH can be used effectively to reduce aryl/aryl and aryl/alkyne ketones in high enantiomeric excess and conversion, provided that the substrate satisfies certain requirements which place them in a ‘window’ of high compatibility with the catalyst.

Study of electronic and steric factors in asymmetric transfer hydrogenation to generate optically active value added chiral alcohol in high enantiomeric excess

ACS Fall 2020 Virtual Meeting

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