Chromatography is a technique used for separating and identifying the constituents in a mixture. Due to the differential retention mechanisms analytes are retained to different extent under the conditions of chromatography. The retention time is usually used to identify a component, by comparing the retention time of a standard with that of a sample. Although this is a relative identification routine it works well for many cases. The challenge however is that retention time is impacted by the concentration of other ions present in the sample therefore relying on retention time alone for identification is not prudent. Also, elution of components near the peak of interest can impact the retention time and shift the peak making identification less facile.  In this presentation, a normalized shape-based method that leverages the profile of a peak during chromatography is used to identify the peaks of interest for ion chromatography.

Peak profile as an indicator of identity in ion chromatography

ACS Fall 2020 Virtual Meeting

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