Cyclodextrins have been used to bind a variety of small molecule guests, with the resulting supramolecular complexes used for high impact applications in diverse research areas including enhanced drug solubilization, environmental remediation, and supramolecular catalysis. Although higher-order cyclodextrin structures have been reported to have improved efficacy, a detailed structure-property relationship around the use of higher order cyclodextrins remains elusive. Reported herein is the design, synthesis, and supramolecular applications of a variety of cyclodextrin nanosponges. By directly comparing the performance of the nanosponges to those of the monomeric cyclodextrin constructs, we have developed a markedly enhanced understanding of the structure-property relationships in higher order architectures as well as extremely high performance in small molecule complexation and detection. We expect that this improved understanding will be of significant interest to other researchers studying cyclodextrin complexation in particular, and supramolecular host-guest complexation in general.<br/>

Higher order cyclodextrin architectures for improved binding and detection capabilities

ACS Fall 2020 Virtual Meeting

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