Alzheimer's disease (AD) is the most common degenerative brain disease, with symptoms impaired cognitive function in the early stages as the disease progresses. We designed an immunosensor to diagnose AD using tear fluid. The platform targets apolipoprotein E (Apo E) is specifically found in tears from AD patients. We using inorganic and organic nanoparticles, can detect biomarkers Apo E, by fluorescent signal. As inorganic nanoparticles, magnitic nanoparticles (MNP) with superparamagnetic property can separate and concentrate the biomarkers. Psomes as organic nanoparticles, are polymeric nanoparticles synthesized using amphiphilic polymers. Since the fluorescent dyes are loaded in the psome's membrane, the amplified fluorescent signal can be expressed in the presence of biomarkers. The immunosenor, consists of magnetic nanoparticles (MNP) and polymersomes (Psomes), has a detection time of less than 1.5 hours and an LOD value of 1 fmol/ml, enabling early diagnosis of Alzheimer's disease.

Polymersome-amplified fluorescence immunoassay (PAFIA): Fluorescence detection platform of Alzheimer's disesase

ACS Fall 2020 Virtual Meeting

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