Developing new polymer post functionalization methods is an essential part of expanding the applications of polymers. Most of these polymer modification reactions deal with introducing one functional group at a time and require multiple steps to introduce complex functionalities. Multicomponent reactions (MCRs) are widely used in organic chemistry to simplify the synthesis of highly functionalized molecules and have great potential for expand the scope of polymer functionalization. Yet its application in polymer functionalization is hindered by the reactive and unpleasant nature of isocyanide group used. In this work, we described a family of novel stable monomers that can be converted to isocyanide readily in both monomer and polymer state and can undergo MCRs using simple one-pot protocol. Block, random and homopolymers of a formamide monomer with other comonomers were tested for efficiency in MCRs. As a function of composition and architecture medium to good conversions were achieved. Further experiments also prove the protocol has a large substrate scope. This family of new monomers allow the introduction of MCRs from organic chemistry onto the polymer post-functionalization.

Formamide based monomers for highly functionalized polymers

ACS Fall 2020 Virtual Meeting

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