ABSTRACT The study of natural products has played a major role in the development of novel therapeutic substance with high efficacy. Mucuna puriens, Newboldia laevis and Pteridium aquilinum are known medicinal plants used in the treatment of many diseases. In this study, the use Mucuna puriens, Neuboldia laevis and Pteridium aquilinum in the treatment of diabetes both singular and combined graded doses were evaluated. Diabetes was induced in wistar albino rats using intraperitoneal injection of 140mg/kg of alloxan. Sixty six rats were randomly divided in 11 groups of 6 rats each (n=6). 5mg/kg of glabenclamide was used as the standard control while different graded doses of the extracts at 200mg/kg and 400mg/kg in single and combined form were administered to the other groups with one untreated group serving as the diabetic control. The study lasted for a period of 21 days. The Extracts in single and combined form significantly (p&lt;0.05) lowered the elevated blood glucose level. The % reduction of the extracts ranged from 44.92% to 68.65% with 400mg/kg of the combined dose having the highest % reduction (68.65%) compared to the standard drug (56.45%). There was also significant (p&lt;0.05) decrease in the glycated hemoglobin, lipid, hematology indices and markers of cellular toxicity compared to the diabetic control (untreated group). The combined extracts effectively ameliorated fatty degeneration and necrosis in the liver and pancreatic hyperplasia in diabetic rats. The combined extracts showed more efficacy than the single graded dose and the glabenclamide. This suggested that the polyherbal formulation enhances therapeutic action and is effective in the treatment diabetes.

Antidiabetic properties of mucuna puriens, newboldia laevis and pteridium aquilinum in single and conbined graded doses in alloxan induced diabetes in rats

ACS Fall 2020 Virtual Meeting

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