ABSTRACT This present study evaluated the effect of methanol leaves extract of Jatropha tanjorensis on some cardiac function biomarkers in isoprenaline induced myocardial infarction in albino rats. Thirty six (36) albino rats were used for the in vivo study and randomly divided into six (6) groups of six rats per group. Group 1 served as the normal control, group 2 was the negative control (administered 85mg/kg of isoprenaline only), group 3 served as the positive control (pretreated with 2mg/kg carvedilol for 28 days, group 4 through 6 were pretreated with 200mg/kg, 400mg/kg and 600mg/kg of methanol leaves extract of Jatropha tanjorensis respectively for 28 days. Myocardial infarction was induced in the rats using subcutaneous injection of 85mg/kg isoprenaline (ISO) for two consecutive days (26th and 27th) at 24hours interval. The acute toxicity study of the extract recorded no death even at the high dose of 5000mg/kg. The results showed that isoprenaline significantly (p&lt;0.05) produced myocardial infarction because there was significant (p&lt;0.05) increase in CK-MB activity, Troponin I activity, LDH acitivity, AST activity, ALT activity, hsCRP concentration, TAG concentration, Cholesterol concentration, and MDA concentration of the negative control group compared to the normal control and treated groups. The extract at the dose of 400mg/kg significantly (p&lt;0.05) decrease lipid and cardiac function biomarkers. There was also significant (p&lt;0.05) increase in HDL concentration and endogenous antioxdant enzymes of the treated groups except the group administered 600mg/kg of the extract which showed significant decrease in the catalase activity. The histopathological study showed different degrees of cardiac alteration. There was marked histomorphological alteration, severe widespread myocardial necrosis of the heart, atrophy of hepatic cord but mild multifocal vascuole degeneration of the renal tubular epithelial lining cell in the group administered 600mg/kg of the extract and the negative control compared to the normal control. This indicated that the extract at 600mg/kg dose does not possess cardioprotective potency. The carvedilol at 2mg/kg dose showed less potency in restoring damage cells. The extract at 400mg/kg dose showed good ability in ameliorating damage cells though it has less cardioprotective activity. This study suggested that the extract to some extent could serve as an agent for the prevention of cardiotoxicity.

Effect of methanol leaves extract of jatropha tanjorensis on some cardiac function biomarkers in isoprenaline induced myocardial infarction in albino rats

ACS Fall 2020 Virtual Meeting

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