Despite the medical advances, numerous disease states can only be explained by complex, multi-molecular interactions rather than by alteration of a single gene, gene product or metabolite. Thus, in order to garner a more complete and relevant understanding of disease, one must obtain a comprehensive perspective of the biological system, thereby uncovering the interdependent and dynamic pathway, network and cellular events that undergo change as a function of disease predisposition, onset and progression. In the last 20 years, researchers have made great efforts to investigate botanical products and to analyze their components. Although many studies were conducted to understand the molecular mechanisms, it is still unclear how the multi-components of complexed phytochemicals interact with multi-targets to exert its therapeutic effects. The current state of data generation (omics) and data analytical (AI) technologies enables the generation of insights into the complexity of interactions between phytochemicals and physiology, leading to better interventions aimed at improving health. The presentation will show a few examples on understanding the complex interactions between phytochemicals and molecular targets and mechanisms of herbal ingredients for human health based on systems biology approach.

Understanding the complexity of interactions between phytochemicals and the network of mechanisms based on systems biology

ACS Fall 2020 Virtual Meeting

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