The protein engineering community now has the capacity to rapidly create synthetic binding proteins with high potency and exquisite selectivity. Although its major focus remains on the development of biologic therapeutics, synthetic binding proteins have proven also to be transformative tools in mechanistic biomedical investigation. I will present applications of the Monobody technology, a synthetic binding protein system based on the fibronectin type III scaffold, to challenging questions in chemical biology and structural biology in which tailor-made Monobodies enable novel investigations and help gain new mechanistic insights.

Enabling chemical and structural biology with synthetic binding proteins

ACS Fall 2020 Virtual Meeting

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